カルチノイドおよび類縁の内分泌癌―本邦症例と外国症例の比較―

DOI Web Site 被引用文献31件 参考文献35件

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  • CARCINOIDS AND THEIR VARIANT ENDOCRINOCARCINOMAS: A COMPARISON BETWEEN JAPANESE AND FOREIGN CASES IN THE CARCINOID GROUP

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The purpose of this study is to provide extensive up-to-date information on carcinoid tumors to investigators actively engaged particularly in the research field of carcinoids and their variant endocrinocarcinomas. A total of 11, 842 cases of endocrinocarcinomas maintained in the Niigata Registry were analyzed. These cases were divided into two main groups: the carcinoid group (n=10, 804) and the variant group (n=1, 038), the former further into the Japanese series (n=4, 549) and the foreign series (n=6, 255). Evaluation of cases in the various categories was performed by the Niigata Registry analyzing system (NUS). The largest number of cases was recorded in the rectum (n=1, 132) followed by the respiratory system, stomach, duodenum and appendix in the Japanese series, and in the respiratory system (n=1, 319) followed by the jejunoileum, appendix, stomach and rectum in the foreign series. The malignant characteristics of carcinoids were evident by an unexpectedly high rate of metastasis in cases with small submucosal lesions of 10 mm or less in diameter, exhibiting 10.0% of 1, 045 cases. An overall significant statistical difference (P<0.01) between the Japanese series and the foreign series was evident in a male/female ratio, age, tumor-size, rate of metastases, and incidence of the carcinoid syndrome. However, such a difference was variably demonstrated when calculated in cases at different sites. Postoperative 5-year survival rates in overall cases after curative resection (Kaplan-Meier) were completely identical with the same curve patterns in both groups showing an average rate of 82.0%.

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