Ｗｅｅｋｌｙ　ｐａｃｌｉｔａｘｅｌ投与が有用であった再発胃癌の１例

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  • A CASE OF RECURRED GASTRIC CANCER IN WHICH WEEKLY PACLITAXEL ADMINISTRATION WAS USEFUL

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We report a case of recurred gastric cancer in a 70-year-old woman to whom weekly paclitaxel administration was useful.<br>The patient had undergone a distal gastrectomy for gastric cancer in April 2001, which was pathologically evaluated as tub2, T2 (SS), ly3, v0, N1, CY1, Stage IV, and CurC. After discharge, the patient had been given UFT (400mg/day) orally but tumor markers became increase since July, 2001. Oral administration of TS-1 (100mg/day) was started in September. The tumor makers once decreased, but increased again and adverse side effects appeared. The TS-1 regimen was withdrawn after three courses. Thereafter obstructive jaundice, paraaortic lymph node swelling, bilateral hydronephrosis, and retention of ascites appeared, and weekly administration of paclitaxel at a dose of 170mg/m2 was started in January 2003. After completion of one course of the regimen, a PTCD tube inserted for obstructive jaundice could be removed, and after three courses a diminishing of swollen lymph nodes, improvement of bilateral hydronephrosis, and disappearance of ascites were identified, resulting in remarkable improvement of the patient's QOL.<br>It is thought that weekly administration of paclitaxel can be an expectable option for recurred gastric cancer.

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