CONCENTRATION OF CLARITHROMYCIN AND 14-R-HYDROXY-CLARITHROMYCIN IN PLASMA OF PATIENTS WITH Mycobacterium avium COMPLEX INFECTION, BEFORE AND AFTER THE ADDITION OF RIFAMPICIN

この論文にアクセスする

この論文をさがす

著者

    • YAMAMOTO F.
    • Division of Internal Medicine, National Ohmuta Hospital
    • HARADA S.
    • Division of Internal Medicine, National Ohmuta Hospital
    • MITSUYAMA T.
    • Division of Internal Medicine, National Ohmuta Hospital
    • HARADA Y.
    • Division of Internal Medicine, National Ohmuta Hospital
    • KITAHARA Y.
    • Division of Internal Medicine, National Ohmuta Hospital
    • YOSHIDA M.
    • Research Institute for Disease of the Chest, Graduate School of Medical, Kyushu University
    • NAKANISHI Y.
    • Respiratory Division, University hospital, Fukuoka University

抄録

Clarithromycin (CAM) and rifampicin (RFP) have both been recognized to be effective antibiotic agents against Mycobacterium avium complex (MAC) infection. Rifamycin derivatives including RFP and rifabutin modulate the CAM metabolism by inducing the hepatic cytochrome p-450 3A4. To clarify the effect of RFP on the CAM metabolism, we measured the plasma concentration of CAM and 14-R-hydroxyclarithromycin (M-5), the major metabolite of CAM, in 9 patients suffering from MAC infection before and after the addition of RFP. After the addition of RFP, the mean plasma concentration of CAM significantly decreased, while that of M-5 did not. In addition, the amount of CAM+M-5 concentration also significantly decreased. As M-5 is less effective against MAC infection than CAM, more attention should thus be paid to the plasma CAM concentration in patients administered CAM and RFP concomitantly.

収録刊行物

  • The Japanese journal of antibiotics

    The Japanese journal of antibiotics 57(1), 124-133, 2004-02-25

    公益財団法人 日本感染症医薬品協会

参考文献:  16件中 1-16件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

ページトップへ