EFFECTS OF CISPLATIN AND PHENYLETHYL ISOTHIOCYANATE ON HEAD AND NECK CANCER CELLS

• TANAKA Nobuyuki

  Department of Otolaryngology, Fukui General Hospital

• SAITO Hitoshi

  Department of Otolaryngology, Fukui Medical University

• FUJIEDA Shigeharu

  Department of Otolaryngology, Fukui Medical University

• OHTSUBO Toshio

  Department of Otolaryngology, Fukui Medical University

• NODA Ichiro

  Department of Otolaryngology, Fukui Medical University

• SUGIMOTO Chizuru

  Department of Otolaryngology, Fukui Medical University

• SUNAGA Hiroshi

  Department of Otolaryngology, Fukui Medical University

• IKAWA Hideki

  Department of Otolaryngology, Fukui Medical University

• KIMURA Yuichi

  Department of Otolaryngology, Fukui Medical University

• SEKI Mizue

  Department of Otolaryngology, Fukui General Hospital

• KIMOTO Hisashi

  Department of Biochemistry I, Fukui Medical University

• TAKETO Akira

  Department of Biochemistry I, Fukui Medical University

Bibliographic Information

Other Title

• 頭頚部癌細胞におけるイソチオシアネート併用によるＣＤＤＰ効果増強の試み　　（第二報）

Abstract

Development of resistance to cisplatin is a major obstacle to successful treatment. Studies were conducted to investigate overcoming resistance to cisplatin. Simultaneous administration of cisplatin and 2-(4-hydroxyphenyl) ethyl isothiocyanate (hITC) to cancer cells increased cell killing and apoptosis induced through a p53-dependent or-independent pathway. And, activation of SAPK/JNK (stress-activated protein kinase/c-Jun N-terminal kinase) was involved in the apoptosis induced by cisplatin and hITC. Taken together with previous findings that p53 mutations are involved in 65% of oral and oropharyngeal cancers, and that cisplatin kills cancer cells mainly by apoptotic induction, it is suggested that hITC may be a useful agent for treatment of cisplatin-resistant cancers or cancers with p53 mutation.

Journal

• Japanese jornal of Head and Neck Cancer

  Japanese jornal of Head and Neck Cancer 27 (1), 244-248, 2001

  Japan Society for Head and Neck Cancer

Keywords

• apoptosis
• cis-diamminedichloroplatinum (II)
• 2-(4-hydroxyphenyl) ethyl isothiocyanate
• p53
• stress-activated protein kinase/c-Jun N-terminal kinase

Details

• CRID: 1390001204727837952
• NII Article ID: 130004063359
• NII Article ID: 10012170405
• NII Book ID: AN00165234
• DOI: 10.5981/jjhnc1974.27.244
• ISSN: 18839878
• ISSN: 09114335
• Web Site: https://search.jamas.or.jp/link/ui/2004063209
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed