腺癌系腫瘍に対する炭素イオン治療の途中解析 PRELIMINARY RESULTS OF CARBON ION RADIOTHERAPY FOR ADENOCARCINOMAS OF THE HEAD AND NECK

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抄録

放医研で行われている頭頸部悪性腫瘍に対する重粒子線 (炭素イオン) 治療において, 1997年4月から2000年8月までに治療された101例中, 腺癌13例, 腺様嚢胞癌16例, 乳頭状腺癌8例の計37例を対象にした途中解析を行った。性別は腺癌で男性11例女性2例, 腺様嚢胞癌で男性6例女性10例, 乳頭状腺癌で男性4例女性4例であった。年齢は腺癌で平均60才, 腺様嚢胞癌で52才, 乳頭状腺癌で69才であった。標的体積の大きさは, 腺癌で平均206ml, 腺様嚢胞癌で210ml, 乳頭状腺癌で253mlであった。炭素イオンは57.6GyE/16回/4週間で35例が照射され, また64.0GyE/16回/4週間で2例が照射されたが, 急性期反応は重篤なものはなく, 全例が予定どおり終了した。腺癌13例の3年局所制御率は91%, 3年生存率は74%であり, 16例の腺様嚢胞癌ではそれぞれ100%と54%, また8例の乳頭状腺癌ではそれぞれ83%と38%である。照射後に遠隔転移が発生し生存率の低下の主因となっている。

Carbon ion radiotherapy for head and neck malignancies, which has been performed since April of 1997, was analyzed preliminarily. Of 101 head and neck patients who were treated till August 2000, 37 cases with adenocarcinomas were analyzed. They consisted of 13 cases of adenocarcinoma (AC), 16 cases of adenoid cystic carcinoma (ACC), and 8 cases with papillary adenocarcinoma (PAC) of the thyroid. There were 11 males and 2 females in AC, 6 males and 10 females in ACC, and 4 males and 4 females in PAC. Age ranged from 45 to 75 (average, 60 years old) in AC, from 39 to 79 (52) in ACC, and from 39 to 78 (69) in PAC. Target volume ranged from 31 to 484cc (average of 206cc) in AC, from 58 to 530cc (210cc) in ACC, and from 108 to 407 (253cc) in PAC. Thirty-five cases were treated with 57.6GyE/16 fractions/4 weeks, and 2 cases were treated with 64.0GyE/16 fractions/4 weeks. There was no acute reaction more than grade 3 (RTOG/EORTC) in normal tissues, and all of the patients completed their scheduled irradiations. The three-year local control rate (LCR) of AC was 91%, and the three-year survival rate (SR) was 74% by the Kaplan-Meier method. In ACC, the three-year LCR was 100% and the three-year SR was 54%. In PAC, the three-year LCR was 83%, and the three-year SR was 38%. There were 2 cases of lymph node metastases, and 3 cases with distant metastases, in AC. Also, there were 2 cases with lymph node metastases, 2 cases with meningeal spread, and 6 cases with distant metastases, in ACC. In PAC, there were 3 cases with lymph node metastases. These metastases were the main causes of death of the patients.

収録刊行物

  • 頭頚部腫瘍

    頭頚部腫瘍 28(1), 192-197, 2002-03-25

    Japan Society for Head and Neck Cancer

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各種コード

  • NII論文ID(NAID)
    10012171258
  • NII書誌ID(NCID)
    AN00165234
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09114335
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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