ヒト喉頭癌における誘導型一酸化窒素合成酵素（ｉＮＯＳ）発現の検討

• 執行 寛

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 野中 聡

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 片山 昭公

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 高原 幹

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 荻野 武

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 今田 正信

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 林 達哉

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

• 原渕 保明

  旭川医科大学耳鼻咽喉科・頭頸部外科教室

書誌事項

タイトル別名

• EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN LARYNGEAL CANCERS

抄録

We examined the expression of inducible nitric oxide synthase (iNOS) in 63 patients with laryngeal squamous cell carcinoma (SCC) who had undergone treatment at our hospital. The iNOS expression was detected by an immunohistologic method using mouse monoclonal antibody against iNOS and the staining intensity was scored. The iNOS expression in cytoplasm of tumor cells was detected in 36 (57.1%) of the 63 laryngeal cancers. The iNOS expression was not correlated with either arising sites, TN clinical classifications, or stages. In early-stage (T1N0, T2N0) diseases treated with radiotherapy alone, patients who experienced local recurrence after complete remission showed significantly higher iNOS scores than patients who did not experience local recurrence (5.0 vs. 2.0, p=0.0053). The disease-free survival rate of patients with iNOS expressions was significantly poorer than that of patients without iNOS expressions. These findings suggest that the iNOS expression may be useful as a factor for predicting local recurrence and prognosis in early-stage laryngeal SCC.

収録刊行物

• 頭頸部腫瘍

  頭頸部腫瘍 29 (1), 230-234, 2003

  日本頭頸部癌学会

キーワード

• 喉頭癌
• 誘導型一酸化窒素合成酵素
• 免疫組織染色

詳細情報

• CRID: 1390282679706183040
• NII論文ID: 120002004302
• NII論文ID: 130004166910
• NII論文ID: 10012172353
• NII書誌ID: AN00165234
• DOI: 10.5981/jjhnc1974.29.230
• ISSN: 18839878
• ISSN: 09114335
• Web Site: https://asahikawa-med.repo.nii.ac.jp/records/2102
• Web Site: https://search.jamas.or.jp/link/ui/2004100950
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可