小児白血病の薬剤感受性研究の成果と治療への応用

• 本郷 輝明

  浜松医科大学小児科

書誌事項

タイトル別名

• Research Results and Therapeutic Applications of In Vitro Drug Sensitivity Testing in Childhood Leukemia.

抄録

Drug resistance is one of the main causes of the ultimate failure of chemotherapy in childhood leukemia. I summarize the development and the results of a literature review on in vitro sensitivity in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), focusing on studies using the 3- (4, 5 dimethylthiazol-2-yl) -2, 5-diphenyl-tetrazolium bromide (MTT) assay. Cell biological features and clinical response to chemotherapy are related to in vitro drug sensitivity. In ALL in vitro sensitivity to prednisolone, L-asparaginase and vincristine are significantly related to the clinical response to combination chemotherapy. In AML, however, an extensive study is required to establish the clinical value of drug sensitivity testing. Possible clinical applications of MTT assays include risk-group stratification, individualized tailored therapy, and rational improvements of current treatment for subgroups of patients with infantile ALL and with Ph₁-positive ALL. The resistance profiles obtained by in vitro testing may be helpful in the rational design of further treatment protocols.

収録刊行物

• 日本小児血液学会雑誌

  日本小児血液学会雑誌 15 (3), 139-149, 2001

  特定非営利活動法人　日本小児血液・がん学会

キーワード

• childhood acute lymphoblastic leukemia
• acute myeloid leukemia
• MTT assay
• in vitro drug sensitivity
• risk-group stratification

詳細情報

• CRID: 1390282679318931072
• NII論文ID: 130004117846
• NII論文ID: 10012210778
• NII書誌ID: AN10080852
• DOI: 10.11412/jjph1987.15.139
• ISSN: 18844723
• ISSN: 09138706
• Web Site: https://search.jamas.or.jp/link/ui/2002043698
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可