-
- Serafini-Cessi Franca
- Department of Experimental Pathology, University of Bologna
-
- 瀬古 玲
- (財)佐々木研究所
書誌事項
- タイトル別名
-
- The Sda Antigen and Its Biosynthetic Enzyme: Differentiation-dependent and Onco-developmentally Regulated Expression.
- Sda コウゲン ト ソノ セイゴウセイ コウソ ブンカ イゾンテキ ナ ソシ
- Differentiation-dependent and Onco-developmentally Regulated Expression
- 分化依存的な、そして発癌-発生過程で制御される発現
この論文をさがす
抄録
The blood group Sda antigen is a carbohydrate structure inherited as a dominant character and the β-linked N-acetylgalactosamine is the immunodominant sugar. This antigen is not confined to red cells but is mainly present in colon and kidney and is excreted in urine associated with the Tamm-Horsfall glycoprotein. A pentasaccharide fragment isolated from the Tamm-Horsfall glycoprotein with the GalNAcβ1, 4 (NeuAcα2, 3) Galβ1, 4GlcNAcβ1, 3Gal structure was found to have a very high Sda activity. The β1, 4-N-acetylgalactosaminyl-transferase involved in the biosynthesis of the Sda antigen (Sda-βGalNAc-transferase) strictly requires in acceptors a terminal galactose residue substituted at the O-3 position with N-acetylneuraminic acid. The tissue distribution of this enzyme correlates with the predominant localization of Sda antigen in kidney and colon. The Sda-βGalNAc-transferase is practically absent in neonatal guinea-pig kidney and in large intestine of suckling rat and is dramatically reduced in human colon carcinomas indicating that the expression is onco-developmentally regulated. In human colon carcinoma cells in culture only Caco-2 cells express the Sda-βGalNAc-transferase at a level that parallels the degree of enterocyte differentiation. A large amount of the enzyme is released in the soluble form by differentiated Caco-2 cells, preferentially from the basolateral face. One may postulate that a reduced susceptibility to infections caused by enterotoxigenic and pyelonephritogenic Escherichia coli strains which specifically bind to the NeuAcα2, 3Galβ-units has been the selective agent responsible for the dominant expression of the Sda-βGalNAc-transferase in distal kidney and colon.
収録刊行物
-
- Trends in Glycoscience and Glycotechnology
-
Trends in Glycoscience and Glycotechnology 8 (42), 279-295, 1996
FCCA(Forum: Carbohydrates Coming of Age)
- Tweet
キーワード
詳細情報
-
- CRID
- 1390282679346804352
-
- NII論文ID
- 10012220307
-
- NII書誌ID
- AA10995236
-
- ISSN
- 18832113
- 09157352
-
- NDL書誌ID
- 4029112
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可