１２歳で発症した若年性悪性貧血ＩＩ型の１例

• 栗山 貴久子

  明石市立市民病院小児科 京都府立医科大学小児科

• 内藤 岳史

  明石市立市民病院小児科

• 橋田 哲夫

  明石市立市民病院小児科

• 大塚 拓治

  明石市立市民病院小児科

• 日比 成美

  京都府立医科大学小児科

• 今宿 晋作

  京都市衛生公害研究所

• 澤田 淳

  京都府立医科大学小児科

書誌事項

タイトル別名

• A Case of Juvenile Pernicious Anemia Type II.

抄録

A 12-year-old boy with pernicious anemia (PA) was reported. He was referred to our hospital because of a general malaise and pallor. The blood examination on admission revealed megaloblastic anemia (RBC 1.21 × 10⁶/μl, Hb 4.7 g/dl, MCV 113.9 fl, MCH 39.2 pg) and neutropenia. Serum vitamin B₁₂ was elevated, and the intrinsic factor antibody and parietal cell antibody were positive. A bone marrow smear showed metaplasia and megaloblastic changes in erythroid cells, and giant metamyelocytes and hypersegmented neutrophils were present. Atrophic gastritis was found by endoscopic examination. Results of a Schilling test with ⁵⁷Co-intrinsic factor and ⁵⁸Co were abnormally decreased (1.43 and 0.41%, respectively). Taken together, he was diagnosed as having McIntyre type II PA. He promptly recovered from anemia by vitamin B₁₂ supplement. However, follow-up endoscopic gastrointestinal examinations are necessary because gastric cancer may occur in the presence of atrophic gastritis.

収録刊行物

• 日本小児血液学会雑誌

  日本小児血液学会雑誌 12 (5), 359-363, 1998

  特定非営利活動法人　日本小児血液・がん学会

キーワード

• pernicious anemia
• childhood
• atrophic gastritis
• autoimmune disease

詳細情報

• CRID: 1390282679319742848
• NII論文ID: 130004345556
• NII論文ID: 10012258799
• NII書誌ID: AN10080852
• DOI: 10.11412/jjph1987.12.359
• ISSN: 18844723
• ISSN: 09138706
• Web Site: https://search.jamas.or.jp/link/ui/1999084847
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可