書誌事項
- タイトル別名
-
- Two Cases of Hemolytic Uremic Syndrome following Bone Marrow Transplantation.
この論文をさがす
抄録
Two cases of hemolytic uremic syndrome (HUS) following allogeneic bone marrow transplantation (BMT) are presented. Case 1 is a 14-year-old boy with acute leukemia who underwent allogeneic BMT from an HLA-matched sibling. His conditioning regimen was total body irradiation, L-PAM and thiotepa, and graft versus host disease (GVHD) prophylaxis consisted of short-term methotrexate (MTX) and cyclosporin A (CyA).At 7 months after BMT, he was admitted with edema on the lower extremities, hypertension, proteinuria, microhematuria and hemolytic anemia. He was diagnosed as having HUS. By stopping CyA administration, symptoms disappeared within 4 weeks. Case 2 is a 13-year-old girl with severe aplastic anemia who underwent allogeneic BMT from an HLA-matched unrelated donor. Her conditioning regimen was thoracoabdominal irradiation, cyclophosphamide and busulfan. GVHD prophylaxis consisted of short-term MTX and CyA. At 7 months after BMT, she showed pancytopenia, hemolytic anemia, proteinuria, microhematuria and hypertension.Similar to Case 1, administration of CyA was discontinued and anticoagulant therapy was employed with rapid improvement of clinical and laboratory findings. Although various factors such as chemotherapy, irradiation and infections are considered to be causal agents, the pathogenesis of HUS following BMT is still unknown. In the present cases, irradiation and viral infections might be involved in the pathogenesis of HUS.
収録刊行物
-
- 日本小児血液学会雑誌
-
日本小児血液学会雑誌 9 (2), 123-127, 1995
特定非営利活動法人 日本小児血液・がん学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679319355136
-
- NII論文ID
- 130004346318
- 10012261142
-
- NII書誌ID
- AN10080852
-
- ISSN
- 18844723
- 09138706
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可