In Vitro Biocompatibility Studies of Fibroblast Cells on Ti-Ta Alloys

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Medical science has enabled the substitution and reinforcement of body organs and tissue through the evolution of better materials. Metallic implants have been utilized to aid in injury wound healing as bone replacements, endoprosthesis, and percutaneous devices. Of concern with metallic devices is the prolonged effects and service life of the implant. It is known that metallic dissolution and premature failure can occur in the body leading to complications for the host. In an effort to provide more corrosion resistant materials with adequate strength for better resistance against high cycle fatigue, Ti–Ta alloys are presented to compete with current, popular materials such as Ti6Al4V . This research focuses on the binary alloy systems of Ti40Ta and Ti50Ta alloys for implant consideration. Three heat-treated versions of the Ti–Ta system that demonstrated high strength properties were also assessed. Cell culture testing of NIH-3T3 fibroblast cells was conducted to perform biocompatibility testing on these metal substrates. MTT cytotoxicity assays were performed to evaluate cellular behavior on the metal substrates. Flow cytometry assays were conducted to analyze rates of cell growth and cycling to determine best surface conditions among these metals. Results indicate very similar cellular activity on the Ti alloys and to a lesser degree on the commercially pure titanium and tantalum. Flow cytometry tests showed similar cellular growth rates on the different materials and on the control plastic. MTT assays indicate a higher degree of proliferation on the Ti–Ta alloys and on the Ti6Al4V . Although the Ti and Ta elemental materials supported slightly fewer cells on their surface, differences were minimal. Ti–Ta alloys appear to be comparable if not slightly more compatible than the standard Ti6Al4V.

収録刊行物

  • Materials transactions

    Materials transactions 43(12), 2991-2994, 2002-12-01

    公益社団法人 日本金属学会

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各種コード

  • NII論文ID(NAID)
    10012328783
  • NII書誌ID(NCID)
    AA1151294X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13459678
  • NDL 記事登録ID
    6394997
  • NDL 雑誌分類
    ZP41(科学技術--金属工学・鉱山工学)
  • NDL 請求記号
    Z53-J286
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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