Tumor-Promoting Activity of 48 kDa Molecular Mass Hyaluronic Acid

この論文にアクセスする

この論文をさがす

著者

抄録

Hyaluronic acid (HA), glycosaminoglycan, has long been implicated in malignant transformation and tumor-promoting activity. We found that 48 kDa molecular mass HA <I>in vitro</I> promotes tumor cell growth and tumorigenesis. The increase of cell growth rate in human hepatoma cells (HepG2 cells, cancer cells) and normal human dermal fibroblasts (NHDF cells, normal cells) treated with 48 kDa HA at 2×10<SUP>−4</SUP> kg/L concentration were 110±0.9% and 103±0.5%, respectively. Colony formation activity of 4.8 kDa HA in cultured Balb/3T3 clone A3111 cells was higher than that of 48 kDa HA . However, transforming activity of HA was significantly showed in 48 kDa HA but not in 4.8 kDa HA . These findings suggest that 48 kDa HA has a tumor-promoting activity stronger than 4.8 kDa HA, because the former increase the cell growth of cancer cells than the latter. The increase of cell growth rate in HepG2 cells (cancer cells) and NHDF cells (normal cells) were compared among various molecular masses of HA.

収録刊行物

  • Materials transactions

    Materials transactions 43(12), 3128-3130, 2002-12-01

    公益社団法人 日本金属学会

参考文献:  20件中 1-20件 を表示

  • <no title>

    LAURENT T. C.

    FASEB J. 6, 2397-2404, 1992

    被引用文献8件

  • <no title>

    ASSMANN V.

    J. Cell. Sci. 111, 1685-1694, 1998

    被引用文献1件

  • <no title>

    LESLEY J.

    J. Biol. Chem. 275, 26967-26975, 2000

    被引用文献2件

  • <no title>

    IIDA N.

    J. Cell. Physiol. 171, 152-160, 1997

    被引用文献1件

  • <no title>

    TSUCHIYA T.

    J. Biomed. Mater. Res. 29, 121-126, 1995

    被引用文献1件

  • <no title>

    TSUCHIYA T.

    J. Biomed. Mater. Res. 31, 299-303, 1996

    被引用文献1件

  • <no title>

    SHAPIRO C. L.

    Cancer Invest. 17, 566-574, 1999

    被引用文献1件

  • <no title>

    KOSAKI R.

    Cancer Res. 59, 1141-1145, 1999

    被引用文献2件

  • <no title>

    ASPLUND T.

    Cancer Res. 54, 4516-4523, 1994

    被引用文献1件

  • <no title>

    BEECH D. J.

    J. Surg. Res. 103, 203-207, 2002

    被引用文献2件

  • <no title>

    THYLEN A.

    Cancer. 86, 2000-2005, 1999

    被引用文献1件

  • <no title>

    LAPCIK J. L.

    Chem. Rev. 98, 2663-2684, 1998

    DOI 被引用文献1件

  • Hyaluronidase can modulate expression of CD44

    STERN R.

    Exp. Cell Res. 266, 167-176, 2001

    被引用文献2件

  • <no title>

    LOKESHWAR V. B.

    J. Biol. Chem. 276, 11922-11932, 2001

    DOI 被引用文献3件

  • <no title>

    BOURGUIGNON L. Y.

    J. Biol. Chem. 276, 48679-48692, 2001

    DOI 被引用文献1件

  • <no title>

    CHIU R. K.

    Exp. Cell. Res. 248, 314-321, 1999

    DOI 被引用文献1件

  • <no title>

    CRAMER J. A.

    Biochim. Biophys. Acta. 1200, 315-321, 1993

    被引用文献1件

  • <no title>

    GOEGAN P.

    Toxic In Vitro 9, 257-266, 1995

    DOI 被引用文献1件

  • <no title>

    CHANG N. S.

    J. Biol. Chem. 276, 3361-3370, 2001

    DOI 被引用文献1件

  • <no title>

    CULTY M.

    J. Cell. Physiol. 160, 275-286, 1994

    DOI 被引用文献1件

各種コード

  • NII論文ID(NAID)
    10012329269
  • NII書誌ID(NCID)
    AA1151294X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13459678
  • NDL 記事登録ID
    6395366
  • NDL 雑誌分類
    ZP41(科学技術--金属工学・鉱山工学)
  • NDL 請求記号
    Z53-J286
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ