抗リン脂質抗体症候群における動脈血栓の発症機序 : β2-グリコプロテインIに特異的なリガンドと自己抗体の関与 A mechanism of development of arterial thrombosis : β2-glycoprotein I-specific ligand and autoantibody

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著者

    • 劉 慶平 LIU Qingping
    • 岡山大学院医歯学総合研究科細胞化学分野 Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry

抄録

β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) appeared in patients with antiphospholipid syndrome (APS). We recently reported that β2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL) and that on of the β2-GPI's major ligands derived from oxLDL, oxLig-1, is 9-(7-ketocholest-5-en-3β-yloxy)-9-oxononanoic acid (J. Lipid Res. 42, 697, 2001). In the present study, it was demonstrated that carboxylated variants of cholesteryl linoleate have a critical role for β2-GPI binding.In vitro experiments indicate that oxLDL was uptaken by macrophages via an interaction among the ligand such as oxLig-1, β2-GPI, and anti-β2-GPI autoantibodies. The uptake was not occurred by cholesterol or its ester without a free carboxyl residue, i.e., cholesteryl lenoleate, by cholesterol, or by 7-ketocholesterol alone, even in the presence of β2-GPI and anti-β2-GPI antibodies. Thus, carboxyl variants of cholesteryl ester specific for β2-GPI may mediate anti-β2-GPI Ab-dependent uptake of oxLDL by macrophages and autoimmune atherogenesis developed in APS.

収録刊行物

  • 岡山醫學會雜誌

    岡山醫學會雜誌 114(1), 39-51, 2002-05-30

    岡山医学会

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各種コード

  • NII論文ID(NAID)
    10012336781
  • NII書誌ID(NCID)
    AN00032489
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00301558
  • データ提供元
    CJP書誌  IR 
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