インターフェロン治療後C型慢性肝炎患者の長期予後 : ウイルス学的著効例, 生化学的著効例と無効例の比較 Long-term prognosis of the chronic hepatitis C patients treated with interferon : Comparison among virological responders, biochemical responders and non-responders

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著者

    • 三宅 正展 MIYAKE Masanobu
    • 岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry

抄録

To evaluate the prognosis of the sustained biochemical responder after interferon (IFN) therapy, we retrospectively studied 252 chronic hepatitis C patients who were treated with IFN. Patients were divided into four groups: group A, sustained virological responders (n=84); group B,sustained biochemical but not virological responders (n=43); group C, incomplete responders (n=64); group D, non responders (n=61). The levels of several liver function tests were evaluated at the end of the observation period (4.2±1.6 years, mean±SD) compared with those at just before IFN therapy. The levels of cholinesterase, albumin, γ-globulin, zinc sufate turbidity test, platelet count and clearance rate of indocyanine green test improved in group A (p<0.05), became worse in group D (p<0.05) and did not change in group B. The incidence of hepatocellular carcinoma was significantly higher in group D than in group B (p<0.01);Kaplan-Meier method, log-rank test). The hazard ratio for hapatocarcinogenesis of the patients in group A and B was significantly lower than that in group C and D (hazard ratio: 0.27, range of 0.08-0.98; p=0.046) adjusted for age, gender, stage and total alcohol consumption.These results suggest that the progress of liver disease and liver carcinogenesis was more suppressed in sustained biochemical responders than in non reponders.

収録刊行物

  • 岡山醫學會雜誌

    岡山醫學會雜誌 114(3), 275-281, 2003-01-31

    岡山医学会

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各種コード

  • NII論文ID(NAID)
    10012337171
  • NII書誌ID(NCID)
    AN00032489
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00301558
  • データ提供元
    CJP書誌  CJP引用  IR 
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