原発性胆汁性肝硬変肝組織におけるFas発現の免疫組織化学的検討 Immunohistochemical Study of Fas in Primary Biliary Cirrhosis

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著者

    • 貴志 文俊 KISHI Fumitoshi
    • 岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 内科学第一 Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry

抄録

The expression of Fas on the epithelial cells of bile ducts was examined in liver specimens from 10 patients with primary biliary cirrhosis (PBC), and 14 patients with chronic hepatitis by both light and electron microscopy using the indirect peroxidase-labeled antibody method. In all patients with PBC, Fas was observed on the surface of epithelial cells of interlobular bile ducts. By electron microscopy, electron-dense reaction products of Fas were detected on the basolateral plasma membrane of the bile duct epithelial cells, as well as on some membranes of the endoplasmic reticulum. Fas was expressed more strongly on the surface of the epitherial cells of interlobular bile ducts in PBC than of those in chronic hepatitis. These findings suggest that increased expression of Fas on such bila ducts may play some role in the pathogenesis of PBC.

収録刊行物

  • 岡山醫學會雜誌

    岡山醫學會雜誌 114(3), 283-288, 2003-01-31

    岡山医学会

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各種コード

  • NII論文ID(NAID)
    10012337202
  • NII書誌ID(NCID)
    AN00032489
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00301558
  • データ提供元
    CJP書誌  IR 
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