Histoplasma capsulatum variety duboisii Isolated in Japan from an HIV-infected Ugandan Patient

DOI PubMed 被引用文献3件 参考文献18件
  • Sharmin Shahana
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Ohori Akira
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Sano Ayako
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Kamei Katsuhiko
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Yamaguchi Masashi
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Takeo Kanji
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Uno Jun
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Nishimura Kazuko
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Miyaji Makoto
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

この論文をさがす

抄録

A strain of Histoplasma capsulatum var. duboisii (deposited as IFM 50954 in Chiba University) was isolated from the cerebrospinal fluid of a female Ugandan patient infected with HIV. The isolate had in vitro urease activity on Christensen's urea agar slants, although the common belief is that H. capsulatum var. duboisii is urease negative, and is, considered one of the characteristic markers that distinguishes the three varieties of H. capsulatum. Forty H. capsulatum var. capsulatum, five H. capsulatum var. duboisii, and five H. capsulatum var. farciminosum isolates were evaluated for urease activity on Christensen's urea agar slants and for other qualitative and quantitative urease assays of activity. All 50 isolates of H. capsulatum used in this study were positive for urease activity, suggesting that urease activity may be universal characteristic of H. capsulatum. We also compared the urease activity and pathogenicity of seven H. capsulatum isolates that convert into yeast-form cells. Although isolate IFM 50954 showed moderate virulence in mice and moderate urease activity among tested H. capsulatum isolates, there was no correlation between level of urease activity and pathogenicity. In addition, scanning electron microscopy revealed that some microconidia of isolate IFM 50954 formed “double-cell” configurations that were attached to each other by narrow bases.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (18)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ