Central Cardiovascular Action of Urotensin II in Spontaneously Hypertensive Rats

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著者

    • LIN Yingzi
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • TSUCHIHASHI Takuya
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • MATSUMURA Kiyoshi
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • FUKUHARA Masayo
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • OHYA Yusuke
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • FUJII Koji
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • IIDA Mitsuo
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

抄録

<B>We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats. In the present study, we have determined the central cardiovascular action of urotensin II in spontaneously hypertensive rats (SHR). Intracerebroventricular (ICV) injection of urotensin II elicited a dose-dependent increase in blood pressure in both SHR and normotensive Wistar-Kyoto rats (WKY). The changes in mean arterial pressure induced by ICV urotensin II at doses of 1 and 10 nmol in the WKY were 8±2 and 23±3 mmHg, respectively. ICV administration of urotensin II caused significantly greater increases in blood pressure in SHR (16±3 mmHg at 1 nmol and 35±3 mmHg at 10 nmol, respectively) compared with those in WKY. Urotensin II (10 nmol) elicited significant and comparable increases in heart rate in SHR (107±10 bpm) and WKY (101±21 bpm). Plasma epinephrine concentrations after ICV administration of 10 nmol urotensin II were 203±58 pmol/ml in SHR and 227±47 pmol/ml in WKY, which tended to be higher than those in artificial cerebrospinal fluid-injected rats (73±7 and 87±28 pmol/ml, respectively, <I>p</I> <0.1). The immunoreactivity of urotensin II receptor GPR 14 was expressed extensively in the glial cells within the brainstem, hypothalamus, and thalamus. These results suggest that central urotensin II may play a role in the pathogenesis of hypertension in SHR. Since GPR 14 was expressed in the glial cells of the brain, urotensin II may act as a neuromodulator to regulate blood pressure. (<I>Hypertens Res</I> 2003; 26: 839-845)</B>

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 26(10), 839-845, 2003-10-01

    The Japanese Society of Hypertension

参考文献:  19件中 1-19件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10012457778
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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