CYP3A4*18: It is not Rare Allele in Japanese Population

• YAMAMOTO Takehito

  Department of Pharmacy, University of Tokyo Hospital

• NAGAFUCHI Nobue

  Department of Pharmacy, University of Tokyo Hospital

• OZEKI Takeshi

  Department of Pharmacy, University of Tokyo Hospital

• KUBOTA Takahiro

  Department of Pharmacy, University of Tokyo Hospital

• ISHIKAWA Hiroshi

  Research and Development, Center for Molecular Biology and Cytogenetics, SRL Inc.

• OGAWA Seishi

  Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo

• YAMADA Yasuhiko

  Department of Pharmacy, University of Tokyo Hospital

• HIRAI Hisamaru

  Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo

• IGA Tatsuji

  Department of Pharmacy, University of Tokyo Hospital

抄録

We sequenced all 13 exons of the CYP3A4 gene derived from 48 Japanese subjects. One subject possess the 20070 T>C mutation in the exon 10 (result in leu293Pro substitution, namely CYP3A4^*18), as heterozygote. Thus, we investigated the frequency of CYP3A4^*18 in 118 Japanese population using polymerase chain reaction-restriction fragment length polymorphism with Msp I and determined that the frequency of the CYP3A4^*18 allele was 1.3%.

収録刊行物

• Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ

  Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ 18 (4), 267-268, 2003

  日本薬物動態学会

キーワード

• CYP3A4
• <i>CYP3A4<SUP>*</SUP>18</i>
• allele frequency
• Japanese
• PCR-RELP

詳細情報

• CRID: 1390001205178604160
• NII論文ID: 10012459039
• NII書誌ID: AA1162652X
• DOI: 10.2133/dmpk.18.267
• ISSN: 18800920
• ISSN: 13474367
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715308922?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715308922?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2004076507
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可