Optical Bioimaging : From Living Tissue to a Single Molecule : Atrio-Ventricular Difference in Myocardial Excitation-Contraction Coupling : Sequential Versus Simultaneous Activation of SR Ca^<2+> Release Units

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Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca<sup>2+</sup> transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca<sup>2+</sup> concentration begins to rise earliest at the Z-line level and becames uniform throughout the cytoplasm within about 10 ms after the onset of the action potential; transsarcolemmal Ca<sup>2+</sup> influx triggers Ca<sup>2+</sup> release from release sites on the junctional sarcoplasmic reticulum (SR) coupled to T-tubules at the Z-line throughout the cytoplasm. In atrial myocytes lacking the T-tubular network, transsarcolemmal Ca<sup>2+</sup> influx during an action potential triggers SR Ca<sup>2+</sup> release only at subsarcolemmal region. SR Ca<sup>2+</sup> release then spreads towards the central region of the cell thourgh a propagated Ca<sup>2+</sup>-induced-Ca<sup>2+</sup> release mechanism. The atrio-ventricular difference in excitation-contraction coupling mechanisms underlies some of the atrio-ventricular difference in response to physiological and pharmacological stimuli.<br>

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 93(3), 248-252, 2003-11-01

    The Japanese Pharmacological Society

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被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10012544819
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    6757773
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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