Nonspecific Effects of the Selective κ-Opioid Receptor Agonist U-50, 488H on Dopamine Uptake and Release in PC12 Cells

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κ-Opioid receptor agonists decrease the levels of extracellular dopamine in vivo and in vitro. However, the mechanism(s) underlying these actions are unclear. The objective of this study was to distinguish between an effect of the selective κ-opioid receptor agonist U-50,488H ((<i>trans</i>-(±)-3,4-dichloro-<i>N</i>-methyl-<i>N</i>-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide methanesulfonate) on secretion and reuptake of dopamine by PC12 cells. The data show that U-50,488H has both a modest effect to increase dopamine release and a more pronounced effect to inhibit dopamine uptake. Neither effect was sensitive to nor-binaltorphimine or naloxone, suggesting that they are not mediated through an opioid receptor.<br>

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 93(3), 372-375, 2003-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10012545336
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    6758103
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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