The Tohoku Study of Child Development : A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children

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著者

    • NAKAI KUNIHIKO
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine
    • SUZUKI KEITA
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine
    • OKA TOMOKO
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine
    • MURATA KATSUYUKI
    • Division of Environmental Health Science, Akita University School of Medicine
    • OKAMURA KUNIHIRO
    • Department of Obstetrics, Tohoku University Graduate School of Medicine
    • HOSOKAWA TORU
    • Department of Human Development, Faculty of Education, Tohoku University
    • KUROKAWA NAOYUKI
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine
    • KAMEO SATOMI
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine
    • SATOH HIROSHI
    • Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine

抄録

Several birth cohort studies have shown adverse effects of perinatal exposures to methylmercury (MeHg) and environmentally persistent organic pollutants (POPs). These chemicals are ingested mainly through fish consumption, but little is known about the hazardous effects in Japanese, whose fish consumption is high. The present study, the Tohoku Study of Child Development, was designed to examine the effects of perinatal exposures to MeHg, polychlorinated biphenyls (PCB), dioxins, pesticides, and other chemicals in Japanese children. Six hundred eighty-seven pregnant women were participated in this study with their written informed consent. Maternal peripheral blood, cord blood, cord tissue, placenta, and breast milk samples were collected for chemical analysis. Maternal hair was also taken for MeHg analysis. Infants born at full term were assessed by neurobehavioral tests: the Brazelton Neonatal Behavioral Assessment Scale at three days old, the Kyoto Scale of Psychological Development and the Bayley Scales of Infant Development at 7 and 18 months old, and the Fagan Test of Infant Intelligence at 7 months old. The children will be continuously followed up to ages 6-7 years. Maternal food intake frequency, maternal IQ, socioeconomic status, and home environment were assessed as covariates. The results of this cohort study will allow us to evaluate associations between the neurobehavioral development of children and perinatal exposures to MeHg and environmentally POPs in Japan.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 202(3), 227-237, 2004-03-01

    Tohoku University Medical Press

参考文献:  44件中 1-44件 を表示

被引用文献:  19件中 1-19件 を表示

各種コード

  • NII論文ID(NAID)
    10012709415
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  CJP引用  IR  J-STAGE 
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