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- Arai Eiichi
- Department of Pathology, Saitama Medical School
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- Yamamoto Toshiyuki
- Department of Dermatology, Tokyo Medical and Dental University
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- Kayano Hidekazu
- Department of Pathology, Saitama Medical School
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- Shimada Tetsuo
- Department of Pathology, Saitama Medical School
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- Shimada Shio
- Department of Pathology, Saitama Medical School
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- Hirose Takanori
- Department of Pathology, Saitama Medical School
書誌事項
- タイトル別名
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- A Case with an Indolent Course
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抄録
True histiocytic sarcoma (THS) is a rare form of malignant neoplasm, which is thought to have a poor prognosis. We report the case of a 47-year-old woman who presented with a solitary cutaneous tumor on the forehead. After excision of the tumor, she had no recurrence or metastasis for 10 years. Microscopic observation showed massive infiltration of histiocytoid tumor cells from the dermis without epidermotropism to the deep muscle layer. The large histiocytoid tumor cells contained folded nuclei with frequent mitoses and abundant cytoplasm, but showed no phagocytosis. Muscle fibers were destroyed by infiltration of the tumor cells. Immunohistochemically, the tumor cells were positive for histiocytic markers (CD68 and lysozyme), but negative for lymphoid and epithelial markers. No rearrangement of the immunoglobulin heavy chain and T-cell receptor β/γ chain genes was demonstrated. Therefore, the lesion was diagnosed as primary cutaneous true histiocytic sarcoma (PCTHS) based on the current, strict definition of histiocytic malignancies. In reviewing the literature, we found that some PCTHSs had an indolent clinical course; therefore, we propose that PCTHSs may have variable prognoses.
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 43 (1), 35-41, 2003
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詳細情報 詳細情報について
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- CRID
- 1390282679677984128
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- NII論文ID
- 10012809377
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- NII書誌ID
- AA11556796
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- ISSN
- 18809952
- 13464280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可