High Brachial-Ankle Pulse Wave Velocity Is an Independent Predictor of the Presence of Coronary Artery Disease in Men

DOI PubMed 59 Citations 49 References
  • IMANISHI Ryo
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University
  • SETO Shinji
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University
  • TODA Genji
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University
  • YOSHIDA Masanori
    Advanced Research Center for Human Sciences, Waseda University
  • OHTSURU Akira
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University
  • KOIDE Yuji
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University
  • BABA Takeshi
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University
  • YANO Katsusuke
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Nagasaki University

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Abstract

Pulse wave velocity (PWV) is an index of arterial stiffness, and a simple device for measuring brachial-ankle PWV (baPWV) has recently been developed. However, the clinical application of baPWV in patients with coronary artery disease (CAD) remains to be fully evaluated. This cross-sectional study was conducted to evaluate whether a higher baPWV predicts the presence of CAD. The baPWV was measured in 123 patients (77 males, 46 females; 63.5±11.8 years) who were undergoing coronary angiography. CAD was defined as >50% diameter stenosis. Hemodynamic data and cardiovascular risk factors were examined according to the presence or absence of CAD. Patients with CAD were significantly older across both sexes. The presence of hypertension and chest pain, but not baPWV, was correlated with CAD in females. The baPWV, and the presence of diabetes, hyperlipidemia, and chest pain were related to the presence of CAD in males. Multivariate logistic regression analysis in male patients showed that baPWV, diabetes, hyperlipidemia, and chest pain were independent risk factors for the presence of CAD. Furthermore, high baPWV in males with or without chest pain had a positive predictive value of 81.8% and 71.7% for the presence of CAD, respectively. In conclusion, high baPWV was shown to be a good independent predictor for the presence of CAD in men. (Hypertens Res 2004; 27: 71-78)

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