Relationship between the Contents of Adrenomedullin and Distributions of Neutral Endopeptidase in Blood and Tissues of Spontaneously Hypertensive Rats

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著者

    • JIANG Wei
    • Institute of Cardiovascular Disease, Peking University First Hospital
    • PAN Chun-Shui
    • Department of Physiology, Peking University Health Science Center
    • CAI Da-Yong
    • Institute of Cardiovascular Disease, Peking University First Hospital
    • QI Yong-Feng
    • Department of Physiology, Peking University Health Science Center
    • TANG Chao-Shu
    • Institute of Cardiovascular Disease, Peking University First Hospital

抄録

<B>Adrenomedullin (ADM) is a multifunctional peptide with important roles in the cardiovascular system, especially in the adjustment of cardiovascular and renal homeostasis. ADM is present in plasma, organs and tissues, and its activity increases during hypertension. It remains unknown whether the clearance of this peptide is altered during hypertension. Neutral endopeptidase (NEP) is the major enzyme in ADM's degradation. We observed the activity and distribution of NEP and the expression of its mRNA in the plasma, cardiac ventricle, aorta, jejunum and kidney of spontaneously hypertensive rats (SHRs) in order to study the possible role of NEP in elevating tissue ADM concentrations during hypertension. ADM and NEP were diffuse in all tissues studied. The level of tissue ADM was generally higher in SHR tissues than in control tissues, except in the renal medulla, and its mRNA expression was higher in all tissues. Plasma NEP activity, general NEP activity and the expression of NEP mRNA in the left ventricle, aorta and jejunum in SHRs was lower than that of controls, and the level of ADM was inversely correlated with NEP activity. NEP activity and mRNA and protein expression in SHR kidneys were higher than in control kidneys; moreover, the ADM content was positively correlated with NEP activity in the renal cortex. NEP activity in the lung of SHRs did not differ from that of controls. Thus, in SHRs, the local concentration and action of ADM in the tissues may be differentially regulated by NEP. (<I>Hypertens Res</I> 2004; 27: 109-117)</B>

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 27(2), 109-117, 2004-02-01

    The Japanese Society of Hypertension

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各種コード

  • NII論文ID(NAID)
    10012843628
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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