Olmesartan Medoxomil, an Angiotensin II Receptor Blocker Ameliorates Insulin Resistance and Decreases Triglyceride Production in Fructose-Fed Rats
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- OKADA Kenta
- First Department of Internal Medicine, Showa University School of Medicine
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- HIRANO Tsutomu
- First Department of Internal Medicine, Showa University School of Medicine
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- RAN Jianmin
- First Department of Internal Medicine, Showa University School of Medicine
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- ADACHI Mitsuru
- First Department of Internal Medicine, Showa University School of Medicine
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Although angiotensin II receptor blockers (ARBs) have been recommended as a first line of anti-hypertensive agents in patients with diabetes, it remains unclear whether ARBs have a favorable effect on insulin action and triglyceride (TG) metabolism, both of which are impaired in type 2 diabetes. In this study we addressed this issue by investigating how a newly developed ARB, olmesartan medoxomil, influenced insulin sensitivity and TG metabolism in fructose-fed rats, a representative animal model of insulin resistance. Olmesartan was administrated as a 0.01% drinking solution ad libitum to rats either fed normal chow or fructose-enriched chow (60%) for 21 days. Olmesartan treatment markedly decreased both systolic and diastolic blood pressure in both chow-fed and fructose-fed animals. The area under the curve of insulin (AUCI) was substantially greater in fructose-fed rats in the intravenous glucose tolerance test, and olmesartan treatment significantly reduced the AUCI. Olmesartan significantly improved the insulin sensitivity index in fructose-fed rats assessed by Bergman’s minimal model without affecting insulin-independent glucose disposal. Olmesartan significantly decreased plasma TG and non-esterified fatty acid levels in fructose-fed rats without affecting lipoprotein lipase mass. The TG secretion rate determined by the triton WR1339 technique was two-fold higher in fructose-fed rats, but olmesartan restored the TG secretion to a normal rate. Olmesartan did not affect plasma parameters, insulin sensitivity or TG metabolism in chow-fed rats. Olmesartan ameliorates insulin resistance and overproduction of TG in fructose-fed rats, and these effects appear to be independent of its hypotensive action. (Hypertens Res 2004; 27: 293-299)
収録刊行物
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- Hypertension Research
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Hypertension Research 27 (4), 293-299, 2004
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390001204719153664
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- NII論文ID
- 10012926008
- 30002004995
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD2cXlsVCqtLk%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 15127887
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可