タンパク質の構造と機能の解明　　プロテオーム解析から構造生物学まで

• 平山 和雄

  味の素（株）中央研究所

書誌事項

タイトル別名

• Study of the Mechanism of Biological Systems Using Mass Spectrometry. From Proteome Analysis to Structural Biology.
• タンパクシツ ノ コウゾウ ト キノウ ノ カイメイ プロテオーム カイセキ カラ コウゾウ セイブツガク マデ
• From Proteome Analysis to Structural Biology
• プロテオーム解析から構造生物学まで

抄録

The development of biochemistry and molecular biology has enabled to study the mechanism of various biological systems, such as protein-protein interactions. However, structural biology has been successfully applied to only a few studies of protein-protein interactions. As the development of technologies of X-ray crystallography and nuclear magnetic resonance spectrometry (NMR), it is now possible to obtain precise information on the tertiary structure of proteins. Mass spectrometry is also an effective tool to analyze the structure of large biomolecules. In addition, computational chemistry plays an important role in the study of the protein-ligand interaction. This paper demonstrates how effective mass spectrometry is in the studies of structure-function relationships of biomolecule networks. Prospects of the mass spectrometers for the study of protein structure is also discussed.

収録刊行物

• 質量分析

  質量分析 48 (5), 289-297, 2000

  一般社団法人 日本質量分析学会

キーワード

• Proteome analysis
• Structural biology
• Nuclear magnetic resonance
• X-Ray crystallography
• Computational chemistry

詳細情報

• CRID: 1390282681470616448
• NII論文ID: 10012972684
• NII書誌ID: AN0010555X
• DOI: 10.5702/massspec.48.289
• COI: 1:CAS:528:DC%2BD3cXos1agt7w%3D
• ISSN: 18804225
• ISSN: 18843271
• ISSN: 13408097
• NDL書誌ID: 5512267
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5512267
• Web Site: http://www.jstage.jst.go.jp/article/massspec/48/5/48_5_289/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可