アミノ糖類の立体異性体識別　　エナンチオマー標識ホスト法を用いるキラル認識ＦＡＢマススペクトロメトリー

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タイトル別名
  • Stereoisomer Discrimination of Some Amino Sugars. Chiral Recognition FAB Mass Spectrometry Coupled with the Enantiomer-Labeled Host Method.
  • アミノ トウルイ ノ リッタイ イセイタイ シキベツ エナンチオマー ヒョウシキ ホストホウ オ モチイル キラル ニンシキ FAB マススペクトロメトリー

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FAB mass spectrometry coupled with the host-guest complexation method was used to distinguish some amino sugars (1-8) including glucosamine, galactosamine, and mannosamine, etc. The method characteristically used a 1:1 mixture of the chiral crown ether host whose enantiomer was isotopically labeled. Diastereomer differentiation of a given amino sugar salt (G+) was simply measured with a given host pair (A or B) (HRRRR:HSSSS-d<sub>6</sub>=1:1) from the peak intensity ratio of the two diastereomeric host-guest complex ions as I[(HRRRR+G)+]/I[(HSSSS-d<sub>6</sub>+G)+]≡IRIS (abbreviation). The stereoisomer differentiation was performed by the IRIS values in the range from 0.4 to 2.0 (for the use of the host pair A) and from 0.4 to 3.4 (for the use of the host pair B). The five underivatized amino sugar hydrochloride salts (1-5) were successfully differentiated using the present chiral recognition FAB mass spectrometry. The stereoisomer-(13C)-labeled guest method was also presensed to evaluate their relative complexation abilities.

収録刊行物

  • 質量分析

    質量分析 48 (3), 231-237, 2000

    一般社団法人 日本質量分析学会

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