エラスターゼ阻害剤投与による食道癌術後の呼吸機能障害抑制

• 竹村 雅至

  大阪市立大学大学院医学研究科消化器外科

• 大杉 治司

  大阪市立大学大学院医学研究科消化器外科

• 李 栄柱

  大阪市立大学大学院医学研究科消化器外科

• 金子 雅宏

  大阪市立大学大学院医学研究科消化器外科

書誌事項

タイトル別名

• Effects of Neutrophil Elastase Inhibitor in Preventing Lung Injury after Esophagectomy for Esophageal Cancer

抄録

We studied the usefulness of administering neutrophil elastase inhibitor following radical esophagectomy for cancer, examining interleukin-6 (IL-6), neutrophil elastase, C-reactive protein (CRP), and the PaO₂/FiO₂ (P/F) ratio, an indicator of respiratory dysfunction. The steroid-only (5) group included 11 patients, the steroid-plus-neutrophil elastase inhibitor (SE) group 11, and the untreated control (N) group 9. Clinicopathologic factors, operative time, and intraoperative blood loss did not differ between groups. The N group showed higher IL-6, neutrophil elastase, and CRP than other groups, while all groups showed similar changes in leukocyte count, aspartate aminotransferase, and alanine aminotransferase. The P/F ratio was higher in the SE group than in other groups from day 1 to 5 after surgery, with no difference between the N and S groups. Preoperative steroid administration thus controls cytokines and neutrophil elastase after esophagectomy for esophageal cancer, while concomitant administration of neutrophil elastase inhibitor may improve postoperative respiratory function.

収録刊行物

• 日本腹部救急医学会雑誌

  日本腹部救急医学会雑誌 24 (4), 727-732, 2004

  日本腹部救急医学会

キーワード

• 胸部食道癌
• エラスターゼ阻害剤
• 呼吸機能障害
• ステロイド

詳細情報

• CRID: 1390001204734184704
• NII論文ID: 130004243325
• NII論文ID: 10013118655
• NII書誌ID: AN10426469
• DOI: 10.11231/jaem1993.24.727
• ISSN: 18824781
• ISSN: 13402242
• Web Site: https://search.jamas.or.jp/link/ui/2004271650
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可