Dehydrotrametenonic Acid and Dehydroeburiconic Acid from Poria cocos and Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β

Abstract

A new lanostane-type triterpene acid, (20ξ)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid), along with a known triterpene acid, dehydroeburiconic acid (2), were isolated from the epidermis of the sclerotia of Poria cocos. The structure of 1 was analyzed on the basis of spectroscopic methods. Compounds 1 and 2 inhibited calf DNA polymerase α and rat DNA polymerase β, with the 50% inhibition values of 45.5 μM (1) and 40.8 μM (2), and 86.5 μM (1) and 30.0 μM (2), respectively.

Journal

Bioscience, Biotechnology, and Biochemistry  

Bioscience, Biotechnology, and Biochemistry 68(2), 448-450, 2004-02-23 

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  13

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    10013142271
  • NII NACSIS-CAT ID (NCID) :
    AA10824164
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09168451
  • NDL Article ID :
    6868634
  • NDL Source Classification :
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-G223
  • Databases :
    CJP  CJPref  NDL  J-STAGE 

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