Degradation of Ethyl Docosahexaenoate by γ-Ray Irradiation and Suppression of This Degradation by Antioxidants

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  • Degradation of Ethyl Docosahexaenoate by .GAMMA.-Ray Irradiation and Suppression of This Degradation by Antioxidants
  • Degradation of Ethyl Docosahexaenoate by ガンマ Ray Irradiation and Suppression of This Degradation by Antioxidants

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Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (logP) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.

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