Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

• LEE Yoon-Bok

  Central Research Institute, Dr. Chung’s Food Co., Ltd. Department of Food Science and Technology and School of Agricultural Biotechnology, Seoul National University

• LEE Hyong Joo

  Department of Food Science and Technology and School of Agricultural Biotechnology, Seoul National University

• KIM Kang Sung

  Department of Food and Nutrition, Yong-in University

• LEE Jae-Yong

  College of Medicine, Hallym University

• NAM Sang-Yoon

  College of Veterinary Medicine, Chungbuk National University

• CHEON Sang-Hee

  Central Research Institute, Dr. Chung’s Food Co., Ltd.

• SOHN Heon-Soo

  Central Research Institute, Dr. Chung’s Food Co., Ltd.

抄録

To examine a potential role for soybean phytoestrogens in postmenopausal bone loss, twenty-four 12-week-old Sprague-Dawley rats were divided randomly into 4 groups and given controlled diets for 16 weeks. The treatment groups were as followed: sham operated, ovariectomized (OVX) control, OVX + isoflavone extract (6.25 g/kg), and OVX + 17β-estradiol (4 mg/kg). OVX treatments reduced femoral and fourth lumbar vertebral bone density and mineral content (p<0.01), decreased uterine weight (p<0.01), accelerated body weight increases (p<0.05), and increased the activities (p<0.01) of both serum alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). Supplementation with isoflavone prevented the losses of bone density and mineral content caused by OVX (p<0.01). Although both isoflavone and 17β-estradiol exhibited similar bone-sparing ability on the OVX-induced bone loss, the effect of isoflavone was not the same as that of 17β-estradiol on the serum ALP and TRAP, body weight increase, and uterine weight change. We concluded that dietary supplementation with soybean isoflavone can prevent postmenopausal bone loss via a different mechanism of estrogen in OVX rats.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 68 (5), 1040-1045, 2004

  公益社団法人 日本農芸化学会

キーワード

• isoflavone
• estrogen
• ovariectomy
• bone
• uterus

詳細情報

• CRID: 1390282681450603776
• NII論文ID: 10013144565
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.68.1040
• COI: 1:CAS:528:DC%2BD2cXkvVCgu7c%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 6957406
• PubMed: 15170107
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6957406
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.68.1040
• Web Site: https://search.jamas.or.jp/link/ui/2006162312
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可