各種浸漬媒体中におけるティッシュコンディショナーからのフタル酸エステルの溶出挙動

  • 川口 稔
    福岡歯科大学歯科医療工学講座生体工学分野
  • 高橋 裕
    福岡歯科大学咬合修復学講座有床義歯学分野
  • 宮崎 光治
    福岡歯科大学歯科医療工学講座生体工学分野

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  • Leaching Behavior of Phthalate Esters for Tissue Conditioners in Various Immersion Media

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Purpose: The amount of leached plasticizers (phthalate esters) for commercially-available tissue conditioners immersed in various immersion media (distilled water, 5% and 10% ethanol) was measured to investigate the leaching and intake behavior.<BR>Methods: Six disk-shaped specimens were immersed in each immersion medium for 14 days. Leached phthalate esters in each immersion medium were measured by high-performance liquid chromatography at days 1, 3, 5, 7, and 14. From the leaching behavior of phthalate esters in each immersion medium, the effect of these media on the amount of leached phthalate ester was investigated.<BR>Results: For three kinds of phthalate ester (dibutyl phthalate: DBP, butyl phthalyl butyl glycolate: BPBG, butyl benzyl phthalate: BBP), immersion in the ethanol aqueous solution increased the amount of leached phthalate esters. The total amount of leached phthalate esters in 10% ethanol aqueous solution was approximately 1.7-2.3 times higher than that in distilled water. Leaching of phthalate esters increased with longer immersion duration for up to 14 days. The chemical structure of these phthalate esters significantly affected their leaching behavior. Phthalate ester, BBP, containing a hydrophobic aromatic ring in the backbone, showed a lower amount of leaching than the others.<BR>Conclusions: The leaching behavior of phthalate esters for tissue conditioner was dependent on the chemical structure, and the solubility of immersion medium with phthalate esters.

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