Apoptosis-inducing effect of fucoxanthin on human leukemia cell HL-60
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- HOSOKAWA Masashi
- Faculty of Fisheries, Hokkaido University
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- WANEZAKI Satoshi
- Faculty of Fisheries, Hokkaido University
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- MIYAUCHI Kozue
- Faculty of Fisheries, Hokkaido University
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- KURIHARA Hideyuki
- Faculty of Fisheries, Hokkaido University
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- KOHNO Hiroyuki
- Department Pathology, Kanazawa Medical University
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- KAWABATA Jun
- Faculty of Agriculture, Hokkaido University
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- ODASHIMA Shizuo
- Department Pathology, Kanazawa Medical University
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- TAKAHASHI Koretaro
- Faculty of Fisheries, Hokkaido University
書誌事項
- タイトル別名
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- Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60.
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抄録
The apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
収録刊行物
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- Food Science and Technology Research
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Food Science and Technology Research 5 (3), 243-246, 1999
公益社団法人 日本食品科学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204455533184
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- NII論文ID
- 10013198567
- 30024724556
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- NII書誌ID
- AA11320122
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- COI
- 1:CAS:528:DC%2BD3cXjtVyguro%3D
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- ISSN
- 18813984
- 13446606
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- HANDLE
- 2115/42695
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可