Aggregability and Post-Transfusion Survival of Canine Platelets in Stored Whole Blood

• TSUCHIYA Ryo

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• YAGURA Hisayo

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• HACHIYA Yoshio

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• MOCHIZUKI Toshihiko

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• FURUICHI Mitsuru

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• HISASUE Masaharu

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• KOBAYASHI Kosaku

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

• YAMADA Takatsugu

  Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University

抄録

The effects of whole blood storage time on platelet aggregation and on post-transfusion platelet survival time were assessed in dogs. Citrate phosphate dextrose adenine-1 (CPDA-1) was used as a blood cell preservative. Storage time dependent decay of platelet aggregability was assessed. Platelet aggregation responses to collagen and ADP were maintained for at least 8 hr at room temperature. During blood storage, immunoglobulin became nonspecifically bound to platelets, suggesting the potential for immune destruction of platelets by the mononuclear phagocyte system after transfusion. To assess this assumption, the survival times of infused platelets, which were stored for 0 to 8 hr in whole blood, were measured. Post-transfusion survival of platelets was not affected by these storage times. These results suggest that canine platelets maintain viability when stored at room temperature for up to 8 hr in CPDA-1 treated whole blood intended for transfusion.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 65 (8), 825-829, 2003

  公益社団法人 日本獣医学会

キーワード

• canine
• platelet transfusion
• storage time
• whole blood

詳細情報

• CRID: 1390282681403037696
• NII論文ID: 10013231052
• NII論文ID: 110003886267
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.65.825
• COI: 1:STN:280:DC%2BD3svhtFOrtA%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 6684489
• PubMed: 12951412
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6684489
• Web Site: http://www.jstage.jst.go.jp/article/jvms/65/8/65_8_825/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004019716
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可