過去１３年間に新規発症し入院治療した１型糖尿病の臨床的特徴―劇症１型糖尿病を明らかにする―

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タイトル別名
  • Clinical Characteristics of Japanese Type 1 Diabetes Mellitus at Onset -Existence of Fulminant Type 1 Diabetes Mellitus-
  • カコ 13ネンカン ニ シンキ ハッショウ シ ニュウイン チリョウ シタ 1ガタ トウニョウビョウ ノ リンショウテキ トクチョウ : ゲキショウ 1ガタ トウニョウビョウ オ アキラカ ニ スル
  • Existence of Fulminant Type 1 Diabetes Mellitus
  • 劇症1型糖尿病を明らかにする

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抄録

Type 1 diabetes mellitus is classified as autoimmune or idiopathic. Rapid-onset type 1 diabetes with pancreatic exocrine dysfunction was defined as fulminant type 1 diabetes mellitus in Japan. We studied the clinical characteristics of 108 patients diagnosed with type 1 diabetes during 13 years and found fulminant type 1diabetes. When onset HbA1c was lower, patients tended to have higher blood glucose (p<0.001), higher age (p<0.05), and lower logarithmic urinary C-peptide (p<0.0001). We studied the GAD antibody in 98 patients.Of these, 13 had negative GAD antibodyand HbA1c of less than 8.5%, suspected to be f-ulminant type 1 diabetes. One patient had diabetic ketoacidosis 6 days after acute pancreatitis onset, 5 did not show increased serum pancreatic amylase, and 1 showed a slight IA-2 antibody increase.Of the 11 with fulminant type 1 diabetes, 9 had HLA DRB 1*0405-DQB 1*0401, as a haplotype susceptible to Japanese type 1 diabetes, and this haplotype may be related to this subtype. More cases should thus be studied to clarify the mechanism behind fulminant type 1 diabetes.

収録刊行物

  • 糖尿病

    糖尿病 47 (3), 209-216, 2004

    一般社団法人 日本糖尿病学会

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