Quinine-resistant Severe Falciparum Malaria Effectively Treated with Atovaquone and Proguanil Hydrochloride Combination Therapy
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- UCHIYAMA Hitoji
- Department of Medicine, Nantan General Hospital
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- OKAMOTO Akio
- Department of Medicine, Nantan General Hospital
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- SATO Katsuaki
- Department of Medicine, Nantan General Hospital
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- YAMADA Tomohiro
- Department of Medicine, Nantan General Hospital
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- MURAKAMI Sadatsugu
- Department of Medicine, Nantan General Hospital
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- YONEDA Seiichi
- Department of Medicine, Nantan General Hospital
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- KAJITA Yoshihiro
- Department of Medicine, Nantan General Hospital
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- TEGOSHI Tatsuya
- Department of Medical Zoology, Kyoto Prefectural University of Medicine
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- ARIZONO Naoki
- Department of Medical Zoology, Kyoto Prefectural University of Medicine
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A 22-year-old Japanese man noticed pyrexia and diarrhea after travel to Guinea. Notable physical findings included hepatosplenomegaly. Treatment with oral quinine and minocycline was started after definitive diagnosis of falciparum malaria by blood smear. Initially, parasitemia and body temperature decreased but by the third night of therapy his temperature increased to 40°C with a slight increase of parasite count. When quinine treatment was changed to atovaquone/proguanil, his temperature dropped immediately and complete plasmodial elimination was confirmed on microscopic examination. Subsequent recrudescence of the disease was not observed. It was concluded that the antimalarial treatment with atovaquone/proguanil might become invaluable in Japan.
収録刊行物
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- Internal Medicine
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Internal Medicine 43 (7), 624-627, 2004
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204868239488
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- NII論文ID
- 10013350196
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD2cvivFymuw%3D%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 7022545
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- PubMed
- 15335195
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可