Multi-drug Resistant Mycobacterium leprae from Patients with Leprosy.

• Maeda Shinji

  Department of Host Defense, Osaka City University Graduate School of Medicine

Bibliographic Information

Other Title

• 薬剤耐性らい菌の出現と迅速検出方法の開発

Abstract

DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.

Journal

• JAPANESE JOURNAL OF LEPROSY

  JAPANESE JOURNAL OF LEPROSY 73 (3), 227-233, 2004

  Japanese Leprosy Association

Keywords

• genetic diagnosis
• anti-leprous chemotherapy
• point mutation
• leprosy
• drug-resistance

Details

• CRID: 1390001206322942592
• NII Article ID: 10013599519
• NII Book ID: AN10559906
• DOI: 10.5025/hansen.73.227
• ISSN: 1884314X
• ISSN: 13423681
• PubMed: 15508725
• Web Site: https://search.jamas.or.jp/link/ui/2004307450
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed