肥満を伴う２型糖尿病患者における減量治療法の新しい試み

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  • New Trial in Diet Therapy for Weight Reduction in Obese Type 2 Diabetic Patients
  • ヒマン オ トモナウ 2ガタ トウニョウビョウ カンジャ ニ オケル ゲンリョウ チリョウホウ ノ アタラシイ ココロミ

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In diet therapy for weight reduction in obesity, an issue is adaptive phenomenon (AP) in which weight loss stops. We evaluated avoiding such AP in obese type 2 diabetic patients. Patients who could be admitted for 8 weeks were put on low calorie diets (LCDs) of 1, 000 kcal/day for men and 800kcal/day for women. To avoid AP, LCDs were switched to standard diets (35kcal/kg standard body weight) for 1 week, then LCDs were started again (Group A, n=15). As a control for the age-matched group, LCDs were continued for 8 weeks despite AP (Group B, n=14). In Group A, all patients avoid AP and continued to lose weight. At 8 weeks after the start of treatment, 12.3±2.5% weight loss was noted. In Group B, the rate of decrease in body weight was 8.8±2.7%. Our method in which energy intake was increased for a short period followed by a return to LCDs was useful for avoiding AP and enhancing weight loss during the same period.

収録刊行物

  • 糖尿病

    糖尿病 47 (8), 635-641, 2004

    一般社団法人 日本糖尿病学会

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