書誌事項
- タイトル別名
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- Regression of Atherosclerosis and Centrally Depressed Lesions in Rabbit Aortas.
- カト タイシュク モデル ニ オケル カンオウセイ ドウミャク コウカセイ ビ
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Atherosclerotic plaque with central depression (depressed lesion) has been hypothesized to be a morphological feature of atherosclerosis regression. We tested this hypothesis in New Zealand white rabbits. After the animals were fed a diet containing 1% cholesterol for three months, they were changed to a normal diet for 6 to 9 months. Several aortas had centrally depressed lesions similar to those found in elderly people, and the animals had low serum cholesterol levels. Immunohistochemical study showed that the depressed lesions contained more smooth muscle cells and collagen type IV, and fewer macrophage-derived foam cells than did common atherosclerotic elevated lesions found in rabbits. We know of no other report of depressed lesions in rabbits with atherosclerosis. Thus we believe that the centrally depressed lesion is a histological characteristic of regression of atherosclerosis.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 34 (7), 555-559, 1997
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205019846528
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- NII論文ID
- 130003652332
- 10013848524
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- NII書誌ID
- AN00199010
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- NDL書誌ID
- 4315487
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- ISSN
- 03009173
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- PubMed
- 9388375
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可