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Home parenteral nutrition (HPN) improved the quality of life in patients with intestinal failure who had used a long-term total parenteral nutrition. To examine some important factors for a long-term HPN, we analyzed several conditions and quality of life (QOL) for a patient who has received HPN_Sfor more than ten years. In this case, excellent SOL has been maintained for a long period without any undesirable clinical pictures or Infections by means of a well-balanced constitutions of lipids and trace elements and good catheter manipulation. These data suggest that HPN_S based on the condition of individual patients are the most important factors for long-term HPNs.