Effects of Orally Administrated Mosapride, a 5-HT4 Receptor Agonist on the Digestive Tract of Horses

• SASAKI Naoki

  Department of Veterinary Surgery, Obihiro University of Agriculture & Veterinary Medicine

• LEE Inhyung

  Department of Veterinary Surgery, Obihiro University of Agriculture & Veterinary Medicine

• AYUKAWA Yu

  Department of Veterinary Surgery, Obihiro University of Agriculture & Veterinary Medicine

• YAMADA Haruo

  Department of Veterinary Surgery, Obihiro University of Agriculture & Veterinary Medicine

抄録

The effects of mosapride, a 5-hydroxytryptamine 4 (5-HT₄) receptor agonist, on the motility of horse small intestine were examined by means of electrointestinography (EIG). Six adult healthy thoroughbreds were used, in which EIG signals from the small intestine were measured by a Degetorappar EGG system. Mosapride, dissolved in 200 ml water, was orally administered at a dose of 2 mg/kg. The total power of EIG signals at a frequency band of 3 cpm was 419.1 ± 122.0 (μV) ² × cpm (n=6) before, and 2,093.6 ± 850.0 (μV)² × cpm (n=6) after the drug administration, the latter mean value being significantly greater than the former. This result suggests that mosapride has a prokinetic action on the motility of horse small intestine.<br>

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｑｕｉｎｅ　Ｓｃｉｅｎｃｅ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｑｕｉｎｅ　Ｓｃｉｅｎｃｅ 15 (3), 81-84, 2004

  日本ウマ科学会

キーワード

• equine
• gastrokinetic agent
• mosapride
• oral administration
• 5-HT₄ receptor agonist

詳細情報

• CRID: 1390282679346196864
• NII論文ID: 120006390017
• NII論文ID: 10014018581
• NII論文ID: 130004431210
• NII書誌ID: AA11010806
• DOI: 10.1294/jes.15.81
• ISSN: 13477501
• ISSN: 13403516
• NDL書誌ID: 7151316
• Web Site: https://obihiro.repo.nii.ac.jp/records/274
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7151316
• Web Site: http://www.jstage.jst.go.jp/article/jes/15/3/15_3_81/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005045717
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可