後天性サイトメガロウイルス感染症小児に合併した免疫学的血小板減少性紫斑病

DOI 被引用文献2件 参考文献13件

書誌事項

タイトル別名
  • Immune Thrombocytopenic Purpura Associated with Acquired Cytomegalovirus Infection in Children

この論文をさがす

抄録

Immune thrombocytopenic purpura (ITP) is an infrequent complication of acquired cytomegalovirus (CMV) infection. We describe two immunocompetent children with ITP, which was associated with CMV infection. We also reviewed reports or abstracts on 13 similarly affected children. Both patients had severe thrombocytopenia and mild increase of serum AST and ALT. Their bone marrow examinations were consistent with platelet consumption. They also had a high titer of anti-CMV IgM in serum. One of them responded to a conventional intravenous high-dose immunoglobulin therapy. The other patient, who failed to respond to the above therapy, was successfully treated with an intravenous high-dose of an anti-CMV high-titered immunoglobulin preparation. A review of the literature showed the characteristics of ITP associated with CMV infection at diagnosis as follows : predominance in males; comparatively severe thrombocytopenia, but a mild bleeding tendency; mild lymphocytosis and mononucleosis in peripheral blood; mild elevation of serum AST and ALT; elevation of platelet associated-IgG in serum; normal or increased counts of megakaryocyte in bone marrow. Half of the patients underwent spontaneous remission or responded to conventional immunosuppressive therapy, but the remaining patients required a more aggressive immunosuppression or CMV-specific therapies. All patients eventually recovered and had no recurrence.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (13)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ