抗炎症薬（フルチカゾン吸入，プランルカスト）の小児気管支ぜん息患者気道過敏性に対する効果

• 岡畠 宏易

  国立大竹病院小児科 現 独立行政法人国立病院機構大竹病院小児科

• 辻 徹郎

  国立大竹病院小児科 現 JA尾道総合病院小児科

• 大黒 一成

  国立大竹病院小児科 現 独立行政法人国立病院機構大竹病院小児科

書誌事項

タイトル別名

• THE EFFECTS OF ANTI-INFLAMMATORY DRUGS (INHALED FLUTICASONE PROPIONATE AND PRANLUKAST HYDRATE) ON BRONCHIAL REACTIVITIES IN BRONCHIAL ASTHMA CHILDREN

抄録

The effects of inhaled fluticasone and pranlukast on bronchial reactivities in 36 mild persistent or moderate persistnet asthma patients aged 7-15 years (22patients treated with inhaled fluticasone and 14 patients with pranlukast) were studied. All patients were treated with those drugs for more than 6 months and showed no asthmatic attacks for more than 5 months. Those patients were also treated only with sustained released theophylline and dosage of inhaled fluticasone, pranlukast and theophylline on each patients were not changed. At the beginning of anti-inflammatory drug treatments and at 6 months after the biginning of the treatments, bronchial reactivities (provocation concentration, PC20) were studied with methacholine. Geometric averages of PC20 in patients who treated with inhaled fluticasone were 243.5μg/mL at the biginning of the treatment and 2074.6μg/mL after 6 months treatments, whereas those of PC20 in patients treated with pranlukast were 238.1μg/mL and 862.7μg/mL, respectively. Both treatments showed statistically significant changes in PC20.<br>Between before and after treatments, PC20 in 13 patients in 22 patients treated with inhaled fluticasone increased more than 8 times, whereas those in 3 patients in 14 patients treated with pranlukast showed more than 8 times increments (p=0.0611). Among 19 patients who showed high bronchial reactivities (PC20≤196μg/mL) before those drugs treatments, their differences were significant (p=0.0238).<br>These results suggested that influences of treatments with inhaled fluticasone or pranlukast on bronchial reactivities in asthma children who did not suffer from asthmatic attacks for more than 5 months after treatments were different, and inhaled fluticasone showed stronger influences in asthma patients' bronchial reactivities than pranlukast.

収録刊行物

• 日本小児アレルギー学会誌

  日本小児アレルギー学会誌 18 (5), 578-585, 2004

  一般社団法人日本小児アレルギー学会

キーワード

• フルチカゾン
• プランルカスト
• 小児気管支喘息
• 気道過敏性
• メサコリン

詳細情報

• CRID: 1390001204475756800
• NII論文ID: 10014071238
• NII書誌ID: AN10064415
• DOI: 10.3388/jspaci.18.578
• ISSN: 18822738
• ISSN: 09142649
• Web Site: https://search.jamas.or.jp/link/ui/2005110653
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可