Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin 2-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

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  • Kyaw Moe
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Yoshizumi Masanori
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Tsuchiya Koichiro
    Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokushima
  • Izawa Yuki
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Kanematsu Yasuhisa
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Fujita Yoshiko
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Ali Nermin
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Ishizawa Keisuke
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine
  • Yamauchi Aiko
    Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, The University of Tokushima
  • Tamaki Toshiaki
    Department of Pharmacology, The University of Tokushima Graduate School of Medicine

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  • Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

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We examined the effects of the stereoisomers of N-acetylcysteine (NAC), <sc>L</sc>-NAC and <sc>D</sc>-NAC, on cellular glutathione (GSH) concentration and whether NAC-regulated cellular GSH levels are directly associated with angiotensin II (Ang II)-induced intracellular signaling events in vascular smooth muscle cells (VSMC). Both <sc>L</sc>-NAC and <sc>D</sc>-NAC similarly increased intracellular GSH concentration. We found that <sc>L</sc>-NAC and <sc>D</sc>-NAC both inhibited Ang II-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and [3H]-thymidine incorporation in VSMC. Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC.<br>

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