計算機科学から生体膜研究へのアプローチ　　脂質膜の構造安定性と透過性の分子動力学シミュレーションによる予測

• 篠田 渉

  産業技術総合研究所計算科学研究部門

書誌事項

タイトル別名

• Molecular Dynamics Study on Stability and Permeability of Lipid Membranes
• コウエンロク シシツ マク ノ コウゾウ アンテイセイ ト トウカセイ ノ ブンシ ドウリキガク シミュレーション ニ ヨル ヨソク

抄録

A slight structural change in lipid molecules sometimes produces dramatic changes in the membrane properties such as structural stability and solute permeability. For example, archaeal lipids bearing ether-linked, highly branched hydrophobic chains form stabile bilayers with low permeability of ionic and nonionic solutes. Nowadays, it is possible to investigate the alteration of the membrane properties induced by a variation of the molecular structure of lipids by using molecular dynamics (MD) simulations. The approach will open a way to design a novel lipid, which should form a membrane with desirable physical properties on the purpose, based upon molecular simulations. In this review, we will introduce a few of our recent MD studies on the effect of chain branching and ether-linkage on the membrane properties.

収録刊行物

• 膜

  膜 29 (6), 353-358, 2004

  日本膜学会

キーワード

• archaeal lipid
• structural stability
• permeability
• lipid membranes
• ether-linkage
• chain branching

詳細情報

• CRID: 1390001206423143168
• NII論文ID: 10014184021
• NII書誌ID: AN0023215X
• DOI: 10.5360/membrane.29.353
• ISSN: 18846440
• ISSN: 03851036
• NDL書誌ID: 7203912
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7203912
• Web Site: https://search.jamas.or.jp/link/ui/2005057677
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可