Slowly Progressive Type 1 Diabetes Mellitus Associated with Vitiligo Vulgaris, Chronic Thyroiditis, and Pernicious Anemia

• SUZUKI Chiori

  Department of Endocrinology, Aomori Prefectural Central Hospital

• HIRAI Yuichi

  Department of Endocrinology, Aomori Prefectural Central Hospital

• TERUI Ken

  Department of Endocrinology, Aomori Prefectural Central Hospital

• KOHSAKA Akira

  Department of Endocrinology, Aomori Prefectural Central Hospital

• AKAGI Tomoaki

  Department of Rheumatology and Hematology, Aomori Prefectural Central Hospital

• SUDA Toshihiro

  Department of Internal Medicine 3, Hirosaki University School of Medicine

抄録

A 81-year-old woman was diagnosed as having diabetes mellitus (DM) at 58 years of age. She started insulin therapy the following year, but her blood sugar levels were poorly controlled. At the age of 75, she tested positive for the anti-GAD antibody (7.8 U/ml) and was diagnosed as having slowly progressive type 1 DM (SPIDDM), as well as vitiligo vulgaris. At 78 years of age, chronic thyroiditis was diagnosed after positive tests for anti-thyroid peroxidase antibody and anti-thyroglobulin antibody. At the age of 81, general fatigue and jaundice appeared concomitantly with severe anemia, with Hb levels at 5.2 g/dl. Low serum vitamin B₁₂ levels and the finding of erythroblastic hyperplasia with megaloblasts in bone marrow led to the diagnosis of pernicious anemia. Anemia was alleviated by intramuscular injections of vitamin B₁₂. The patient developed chronic thyroiditis, vitiligo vulgaris, and pernicious anemia concomitantly with SPIDDM, and was diagnosed as having polyglandular autoimmune syndrome type III. Attention should be paid to these potentially associated autoimmune diseases in daily practice during the follow-up of SPIDDM patients.

収録刊行物

• Internal Medicine

  Internal Medicine 43 (12), 1183-1185, 2004

  一般社団法人 日本内科学会

キーワード

• slowly progressive type 1 diabetes mellitus
• polyglandular autoimmune syndrome
• vitiligo vulgaris
• chronic thyroiditis
• pernicious anemia

詳細情報

• CRID: 1390282679845535744
• NII論文ID: 10014210133
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.43.1183
• COI: 1:STN:280:DC%2BD2M%2FhvFeqsg%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• NDL書誌ID: 7190436
• PubMed: 15645655
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7190436
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/43/12/43_12_1183/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005217823
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可