Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Polymorphism Is Not Associated with Essential Hypertension and Type 2 Diabetes Mellitus in Chinese Population

• CHEN Shufeng

  Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

• YAN Weili

  Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

• HUANG Jianfeng

  Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

• YANG Wenjie

  Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

• GU Dongfeng

  Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

書誌事項

タイトル別名

• Peroxisome Proliferator-Activated Receptor-.GAMMA. Coactivator-1.ALPHA. Polymorphism Is Not Associated with Essential Hypertension and Type 2 Diabetes Mellitus in Chinese Population

抄録

To investigate whether variations in the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) are associated with essential hypertension and type 2 diabetes in a Chinese population. A case-control study design was applied in a Chinese population. Two single nucleotide polymorphisms (SNPs), +1302G>A and G482S, in the PGC-1α gene were genotyped and compared between 494 unrelated Chinese subjects with essential hypertension and type 2 diabetes and 555 normal control subjects with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. These two polymorphisms were in highly significant linkage disequilibrium with each other (p <0.0001). The frequency of the 482S allele was 42.9% in the Chinese population, which was similar to the frequency in the Japanese population (43.7%), but much higher than those of Caucasian populations (30.8% to 38.1%). There were no associations of the G482S and +1302G>A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes. In addition, no associations were found between these two polymorphisms and blood pressure. In conclusion, these results indicated that these two variations in the PGC-1α gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here. (Hypertens Res 2004; 27: 813-820)

収録刊行物

• Hypertension Research

  Hypertension Research 27 (11), 813-820, 2004

  日本高血圧学会

キーワード

• <B>hypertension</B>
• <B>type 2 diabetes</B>
• <B>peroxisome proliferator-activated receptor-γ coactivator-1α</B>
• <B>association study</B>

詳細情報

• CRID: 1390001204720283264
• NII論文ID: 10014387587
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.27.813
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 15824463
• Web Site: https://search.jamas.or.jp/link/ui/2005233082
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可