原発性副甲状腺機能こう進症を併発した胃原発GISTの1例

  • 櫻井 健一
    日本大学医学部外科学講座乳腺内分泌外科部門
  • 天野 定雄
    日本大学医学部外科学講座乳腺内分泌外科部門
  • 柏尾 光彦
    日本大学医学部外科学講座乳腺内分泌外科部門
  • 榎本 克久
    日本大学医学部外科学講座乳腺内分泌外科部門
  • 松尾 定憲
    日本大学医学部外科学講座乳腺内分泌外科部門
  • 根岸 七雄
    日本大学医学部外科学講座乳腺内分泌外科部門

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タイトル別名
  • A CASE OF GASTROINTESTINAL STROMAL TUMOR OF THE STOMACH WITH AN ADENOMA OF THE PARATHYROID

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We report a case of gastrointestinal stromal tumor (GIST) of the stomach with an adenoma of the parathyroid. A 68-year-old man was admitted to the hospital because of low grade anemia. A submucosal tumor of about 4 cm in diameter situated in the gastric fornix was discovered by upper gastrointestinal endoscopy. Since he also had hypercalcemia and hyperparathyroinizum, we searched the origin of the hypercalcemia, and recognized a swelling of the parathyroid. A local excision of the stomach with fundplication was performed, and one month later parathyroidectomy was performed. Histologically, the parathyroid tumor was an adenoma. The gastric tumor was a submucosal tumor with central delle and consisted of proliferation of spindle-shaped neoplastic cells with rather in frequent mitotic figures (3 mitoses per 10 high-power fields). Immunohistochemically, the neoplastic cells displayed diffuse positive reactions to antibodies CD34, c-kit, Desmin, α-SMA and S-100. The frequency of positive reaction with antibody ki-67 was less than 5% in the tumor. The gastric tumor was therefore inferred to be GIST of the combined smooth neuroral-muscular type with low grade malignancy. The patient's postoperative course was excellent, and now he is followed in the outpatient clinic at our hospital without recurrence or metastasis of the tumor. There have been no reports on GIST associated with adenoma of the parathyroid. So this case is presented here because it is thought to be valuable, though no etiological relation between the both diseases is obscure.

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