C-Reactive Protein and Peripheral Artery Disease among Japanese Elderly: the Tsurugaya Project

• HOZAWA Atsushi

  Department of Public Health and Forensic Medicine, Department of Tohoku University Graduate School of Medicine

• OHMORI Kaori

  Department of Public Health and Forensic Medicine, Department of Tohoku University Graduate School of Medicine

• KURIYAMA Shinichi

  Department of Public Health and Forensic Medicine, Department of Tohoku University Graduate School of Medicine

• SHIMAZU Taichi

  Department of Public Health and Forensic Medicine, Department of Tohoku University Graduate School of Medicine

• NIU Kaijun

  Division of Medicine and Science in Sports and Exercise, Department of Tohoku University Graduate School of Medicine

• WATANDO Aya

  Division of Geriatric and Respiratory Medicine, Department of Tohoku University Graduate School of Medicine

• EBIHARA Satoru

  Division of Geriatric and Respiratory Medicine, Department of Tohoku University Graduate School of Medicine

• MATSUI Toshifumi

  Division of Geriatric and Respiratory Medicine, Department of Tohoku University Graduate School of Medicine

• ICHIKI Masataka

  JR Sendai Hospital

• NAGATOMI Ryoichi

  Division of Medicine and Science in Sports and Exercise, Department of Tohoku University Graduate School of Medicine

• SASAKI Hidetada

  Division of Geriatric and Respiratory Medicine, Department of Tohoku University Graduate School of Medicine

• TSUJI Ichiro

  Department of Public Health and Forensic Medicine, Department of Tohoku University Graduate School of Medicine

抄録

We investigated the cross-sectional relationship between ankle brachial index and cardiovascular disease risk factors, including C-reactive protein (CRP), among Japanese elderly, a topic which has had little prior epidemiologic study. Our study population comprised 946 subjects aged at least 70 years in whom both CRP and ankle brachial index were measured. The participants were classified into a low (ankle brachial index<0.9) and normal ankle brachial index group. We found that current smoking, high-density lipoprotein cholesterol <40 mg/dl, a low body mass index (continuous variable), hypertension, diabetes and statin use were all significantly related to a lower ankle brachial index. Higher log-transformed CRP level was significantly related to a lower ankle brachial index after adjustment for the cardiovascular risk factors mentioned above (p <0.01). The odds ratios for low ankle brachial index compared to 0-1 risk factors were 5.79 (95% confidence interval [CI]: 2.99-11.20) for 2 risk factors and 17.45 (95% CI: 6.78-49.91) for 3 or more risk factors; independently of other risk factors, the odds ratio for CRP>1.0 mg/l was 2.10 (95% CI: 1.13-3.88) compared to lower CRP values. Thus, a high level of CRP is related to a low ankle brachial index among Japanese elderly as well as Western subjects. This is the first study to report the relationship between CRP and low ankle brachial index among Japanese elderly. (Hypertens Res 2004; 27: 955-961)

収録刊行物

• Hypertension Research

  Hypertension Research 27 (12), 955-961, 2004

  日本高血圧学会

キーワード

• <B>C-reactive protein</B>
• <B>cardiovascular risk factors</B>
• <B>ankle brachial index</B>
• <B>Japanese</B>
• <B>elderly</B>

詳細情報

• CRID: 1390282679695901440
• NII論文ID: 10014466882
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.27.955
• COI: 1:CAS:528:DC%2BD2MXjvVGhtLY%3D
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 15894836
• Web Site: https://search.jamas.or.jp/link/ui/2005233152
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可