破砕食摂取と普通食摂取によるインスリン分泌の差

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  • The Difference in Insulin Secretion of Crushable Food Intake and Ordinary Food Intake

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The satiety center and feeding center adjust appetite and control diet behavior . Histamine, which is an antifeedant, was found to be secreted by mastication, i.e. chewing stimulation by the genetically obese animal the Zucker rat. In our previous study, the effect of mastication was examined using a chewing gum, and from the result, it was suggested that mastication is associated with the central nervous system. In the present study, for the purpose of examining the relationship between mastication and insulin secretion, food of the same energy but with different hardness was given to the following subjects.<BR>The subjects were 25 healthy females aged 18 to 24 years and were instructed to masticate ordinary food and crushable food. They were grouped into a high mastication group and low mastication group after evaluating their ability to masticate using a mastication test gum . Blood was collected from the cubital vein 4 times in total, at fasting state and 30, 60 and 120 minutes after meal, and the blood glucose and plasma insulin levels were measured. As a result of analysis of the blood glucose and plasma insulin levels classified by the ability to masticate in the ordinary food intake group and the crushable food intake group, no statistically significant difference was observed. In the high mastication group, the blood glucose and plasma insulin levels were analyzed statistically between the ordinary food intake group and crushable food intake group, but no significant difference was observed. However, when the blood glucose and plasma insulin levels between the ordinary food intake group and the crushable food intake group were analyzed in the low mastication group, it was found that the plasma insulin level 30 minutes after meal was higher in the crushable food intake group than in the ordinary food intake group with a statistically significant difference. No glucose tolerance abnormality or insulin resistance was detected from the subjects. In the low mastication group, therefore, it was thought that stimulation by mastication was conveyed to the central nervous system because of the ingestion of crushable food, and the secretion volume of insulin increased with a significance difference .

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